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The Infectious disease and cardiology team at CHLA would like to alert you cases that have been identified at CHLA referred to as Pediatric Inflammatory Multisystem Syndrome with SARS-CoV-2 (PIMS).  The manifestations range from a syndrome similar to Kawasaki Disease to Toxic shock syndrome.


Clinicians should be alert for patients with  high fever that is persisting for 4 days or more, with other symptoms that may include

  • Rash

  • Mucosal changes- red, cracked lips; red tongue

  • Bilateral bulbar conjunctival injection without exudate

  • Swollen and/or red hands and feet

  • Cervical enlarged lymph node

  • Abdominal pain without another explanation

  • Fever for 7 or more days in an infant , for which another explanation has not been identified


Click here to read a PDF from the Royal College of Paediatrics and Child Health on cases there.  Interestingly, in the UK, they note that these children may have SARS-CoV-2 PCR that is positive or negative.


CHLA is ready to treat these patients with a multidisciplinary collaborative approach, and there is a clinical plan in place to assure prompt testing and treatment.


It is also recommended to include this in your anticipatory guidance to families who have children with COVID-19 exposures with strict call back/return precautions for any of these symptoms.  

Please keep the information confidential and not share on social channels as CHLA has not formally released a statement. 

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